Our Technology

Vivacitas is leading the charge in the battle against cancer with our proprietary technologies.

AR-67 is a synthetic compound originally derived from a plant but which can now be manufactured in a laboratory through Vivacitas’ patented technology.
While earlier generations of naturally-sourced Camptothecins treatments generally work the same way, AR-67 provides significant advantages:
  • Design modifications of the natural Camptothecin ‘scaffold’ to increase blood stability, cell membrane penetration and improve tolerability.
  • Our unique, patented chemical synthesis technology to manufacture pure and high quality active product.

Proprietary Synthesis Method

While earlier generations of naturally-sourced Camptothecins treatments generally work in the same way, the aspects that give AR-67 the edge are design modifications of the natural Camptothecin ‘scaffold’ and our unique, proprietary synthesis technology.

Controlled and Consistent Quality

Our patented, total synthetic production is intended to provide more consistent supply and uniformity in quality and consistency, which we anticipate will translate to improved efficacy and tolerability for patients, as signaled in initial Phase I and II clinical studies.

Unique, Patented Innovation

Rather than relying on the organic source material, we can chemically synthesize the active component, which provides a level of independence from harvesting seasonally variable plant-based raw materials and potentially challenging supply chains. The benefit of this is the potential for a more controlled, consistent, scalable, and high-quality product

Our Difference: Manufacturing

  • Proprietary chemical synthesis process
  • Efficient synthetic manufacturing
  • Consistent production potential
  • Rigorous quality control and safety
  • Independence from plant based materials
AR-67 has the potential to deliver the efficacy of Camptothecins with significantly less gastrointestinal and hematological toxicity than Irinotecan. That could be a game changer for patients with gastrointestinal cancers.
Dr. Gerard Blobe, MD, PhD.Duke University School of Medicine.
AR–67 is a next generation camptothecin optimized for fewer side effects and blood-brain-barrier penetration. In glioblastoma patients treated with AR-67 on a clinical trial at our center, we saw encouraging outcomes and tumor shrinkage. AR-67 was extremely well tolerated. I believe AR-67 represents a novel approach in treating this devastating disease.
Dr. Jai Grewal, MD.NSPC Brain and Spine Surgery, NY

References

1. Novel silatecan displays high lipophilicity, improved blood stability and potent
anticancer activity. Bom D, et al J Med Chem 2000; 43:3970-3980

2. Silatecan DB-67 is a novel DNA Topo-1 targeted radiation sensitizer: Chen AY. Mol
Cancer Ther 2005; 4(2): 317-24.

3. Phase I study publication: Arnold SM, et al. Clin Cancer Res. 2010;6:673-680

4. Phase II study publication (abstract): Kumthekar P, et al. SNO 2019. Poster ACTR-40,
published in Neuro-Oncology(https://academic.oup.com/neuro-oncology)

5. Ubiquitin-dependent Destruction of Topoisomerase I Is
Stimulated by the Antitumor Drug Camptothecin*, Desai et al. The Journal of Biological Chemistry, Vol. 272, No. 39, Issue of September 26, pp. 24159–24164, 1997.  https://www.jbc.org

6. Metabolic Pathways of the Camptothecin Analog AR-67, Horn et al. Drug Metabolism and Disposition, Vol. 39, No. 4, 37390/3672838, 2011. https://dmd.aspetjournals.org