Peter Seperack, PhD, JD

Executive Director – Intellectual Property

Dr. Seperack has spent the last 32 years as a biopharmaceutical researcher and as a Biotech patent attorney. As a Post-Doctoral Fellow Dr. Seperack discovered the molecular mechanism of a murine coat color mutation which was a novel member of the non-muscle myosin gene family. As a scientist at Bayer, Dr. Seperack developed models to screen compounds to treat osteoarthritis. Following his scientific career, Dr. Seperack became a patent attorney, and in the law firm environment, prosecuted patents directed to numerous biotech applications. As In-House counsel, Dr. Seperack drafted applications that resulted in a corporate acquisition, and managed a patent department that was prosecuting chemical and biological patent applications. Dr. Seperack managed small molecule portfolios while drafting and prosecuting biological applications. He received his PhD from SUNY Stony Brook, and his JD from Golden Gate University.

References

1. Novel silatecan displays high lipophilicity, improved blood stability and potent
anticancer activity. Bom D, et al J Med Chem 2000; 43:3970-3980

2. Silatecan DB-67 is a novel DNA Topo-1 targeted radiation sensitizer: Chen AY. Mol
Cancer Ther 2005; 4(2): 317-24.

3. Phase I study publication: Arnold SM, et al. Clin Cancer Res. 2010;6:673-680

4. Phase II study publication (abstract): Kumthekar P, et al. SNO 2019. Poster ACTR-40,
published in Neuro-Oncology(https://academic.oup.com/neuro-oncology)

5. Ubiquitin-dependent Destruction of Topoisomerase I Is
Stimulated by the Antitumor Drug Camptothecin*, Desai et al. The Journal of Biological Chemistry, Vol. 272, No. 39, Issue of September 26, pp. 24159–24164, 1997.  https://www.jbc.org

6. Metabolic Pathways of the Camptothecin Analog AR-67, Horn et al. Drug Metabolism and Disposition, Vol. 39, No. 4, 37390/3672838, 2011. https://dmd.aspetjournals.org